Gene transcriptions/SAREs

"Salicylic acid (SA) is an important signal in plant defence [4••] and a SA-response element (SARE) has been identified in the tobacco PR2-d gene. A 76bp fragment conferred a 20-fold induction by SA in transgenic tobacco plants and protein binding studies indicated that the core sequence of this SARE is TTCGACCTCC [40]."

Synaptic Activity-Responsive Elements
"A unique synaptic activity-responsive element (SARE) sequence, composed of the consensus binding sites for SRF, MEF2 and CREB, is necessary for control of transcriptional upregulation of the Arc gene in response to synaptic activity."

CREBs
"The Ca2+/cAMP response element-binding protein (CREB) was initially identified as the main interlocutor in the dialogue between the synapse and the nucleus [1]."

MEF2s
"MEF2 [is a transcription factor] necessary for long-term memory consolidation and storage."

Myocyte enhancer factor-2 (MEF2) proteins are a family of transcription factors which through control of gene expression are important regulators of cellular differentiation and consequently play a critical role in embryonic development. In adult organisms, Mef2 proteins mediate the stress response in some tissues.

SRFs
The "serum response factor SRF [is a transcription factor] necessary for long-term memory consolidation and storage."

The serum response factor (SRF) is a transcription factor protein that binds to the c-fos serum response element (SRE).

The serum response factor is a member of the MADS-box (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors, binding to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation, is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).

SRF is important during the development of the embryo, as it has been linked to the formation of mesoderm. In the fully developed mammal, SRF is crucial for the growth of skeletal muscle. Interaction of SRF with other proteins, such as steroid hormone receptors, may contribute to regulation of muscle growth by steroids.

Interactions
Serum response factor has been shown to interact with:


 * ASCC3,
 * ATF6,
 * CEBPB,
 * CREB-binding protein,
 * ELK4,
 * GATA4,
 * GTF2F1,
 * GTF2I,
 * Myogenin,
 * NFYA,
 * Nuclear receptor co-repressor 2,
 * Promyelocytic leukemia protein and
 * Src, and
 * TEAD1.