Genetics/CLEC2D

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene. It is called C-type lectin-like because it has lost the Ca2+-dependent carbohydrate recognition domain present in most conventional C-type lectins while maintaining partial structural similarities. It is one of six genes located in human chromosome region 12p13.31. Several CLEC2D gene transcripts have been described. They are expressed primarily in hematopoietic cells. Lectin-like transcript 1 (LLT1) is expressed on the surface of natural killer cells and some T-cells. Its ligand is CD161.