PlanetPhysics/Bessel Functions Applications to Diffraction by Helical Structures

Applications of Bessel functions in Physics and Engineering
One notes also that Bessel's equation arises in the derivation of separable solutions to Laplace's equation, and also for the Helmholtz equation in either cylindrical or spherical coordinates. The Bessel functions are therefore very important in many physical problems involving wave propagation, wave diffraction phenomena--including X-ray diffraction by certain molecular crystals, and also static potentials. The solutions to most problems in cylindrical coordinate systems are found in terms of Bessel functions of integer order ($$\alpha = n$$), whereas in spherical coordinates, such solutions involve Bessel functions of half-integer orders ($$\alpha = n + 1/2$$). Several examples of Bessel function solutions are:

heat conduction in a cylindrical object
 * 1) the diffraction pattern of a helical molecule wrapped around a cylinder computed from the Fourier transform of the helix in cylindrical coordinates;
 * 2) electromagnetic waves in a cylindrical waveguide
 * 3) diffusion problems on a lattice.
 * 4) vibration modes of a thin circular, tubular or annular membrane (such as a drum, other membranophone, the vocal cords, etc.)

In engineering Bessel functions also have useful properties for signal processing and filtering noise as for example by using Bessel filters, or in FM synthesis and windowing signals.

Applications of Bessel functions in Physical Crystallography
The first example listed above was shown to be especially important in molecular biology for the structures of helical secondary structures in certain proteins (e.g. $$\alpha-helix$$) or in molecular genetics for finding the double-helix structure of Deoxyribonucleic Acid (DNA) molecular crystals with extremely important consequences for genetics, biology, mutagenesis, molecular evolution, contemporary life sciences and medicine. This finding is further detailed in the next subsection.

X-Ray Diffraction Patterns of Double-Helical Deoxyribonucleic Acid (DNA) Crystals
Francis C. Crick (Nobel laureate in Physiology and Medicine in 1962) published in Acta Crystallographica (1952;1953a,b) concise papers on X-ray diffraction patterns of a helix and coiled coils, respectively in which he showed that such patterns can be completely described by the Bessel functions defined above. Thus, the equatorial, or 0-layer, line contained diffraction intensities whose values were computed with the $$J_0$$ Bessel function of the first kind with $$n=0$$. In fact, the entire X-ray diffraction, multiple diamond-like pattern of such helices, including those of the double helical DNA molecule, could be completely computed by means of Bessel functions of different order for each layer line; note however that there have also been occasional contenders to this analysis. In fact, these involve Fourier--Bessel series based on Bessel functions.

There are, however, marked differences between the as shown by this web link which makes a comparison between the images published by H.R. Wilson. The Bessel function and Fourier--Bessel series analysis is however only applicable to the analysis of A-DNA patterns, whereas the X-Ray diffraction/scattering pattern of the B-DNA form is much less tractable although it is the predominant hydrated form in living cells.

The following is a web link to a

Note also that a pairing of double helices of a DNA G-quadruplex has also been recently discovered that might be associated with the initiation of certain cancers; the square of the Fourier transform of such DNA G-quadruplex structures would still result in diffraction patterns constructed from Bessel functions but the new quadruplex symmetry of the `mutated' DNA G-quadruplex would naturally alter the overall diffraction pattern intensities.

Further details and implications for both genomic and biotechnology applications are presented in a related entry on molecular models of DNA.