Progress and Prospects in Parkinson's Research/Symptoms/Motor fluctuations

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Motor fluctuations

'On-off' periods, wearing off, dose failures, and freezing associated with long-term levodopa use

The following references are relevant:-

Bordelon et al (2011) Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease  /

Bohnen et al (2011)  Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson’s disease 

Mera et al (2012) Feasibility of home-based automated Parkinson’s disease motor assessment