Talk:Progress and Prospects in Parkinson's Research/Pathogenesis

In an email of 8th July 2012 HAPE said: "The central section on Pathogenesis currently lacks structure.  This is partly because this delves into advanced microbiological concepts difficult to translate for the laymen." Droflet replied: ''"I think that this needs to take a top-down approach. I have tried to start this off in the Current Parkinson's Paradigm page: http://en.wikiversity.org/w/index.php?title=Current_Parkinson's_Paradigm. Subpages could then look at the subject from different angles such as those you suggest below as they are all equally valid ways of discussing pathogenesis.  I see the topic as an essay with references to the seminal research.  A sort of review article which gets updated as new results and new ideas come in.  I think the problem with looking at it from the point of view of research establishments is that their publications often seem to disregard other topics that we as onlookers would also feel relevant.  E.g. the alpha-synuclein people tend not to mention the mitochondrial dysfunction and inflammation and oxidative stress aspects that I feel are all involved in the overall pathogenesis. Yet there are certain centres which do take a better bird's eye view such as the Oxford PDC and SiTRan in Sheffield."''

HAPE also wrote: "I wondered whether to structure it by affected organelles, but one piece of research can relate to several of these.

"So what about metabolic pathways.  Some of these seem to recur frequently e.g. alpha synuclein malformation, Complex 1 mitochondrial disruption, and interruptions to microtubule trafficking.   But there are thousands of potential pathways to cater for and how do you assemble a logical structure to contain them?"

Droflet commented: ''"As I say, I would favour the top-down approach where a hypothesis is described of how they all fit in and contribute and references and sub-pages are provided to fill in the details. Someone could start it off and indicate what sub pages need to be provided and other people could work on those details." ''

HAPE also wrote: "So I was wondering whether to structure this part of the wiki by devoting pages to PD research establishments.  These publish streams of papers following a particular pathogenetic theme.   They might even be persuaded to take an interest in the wiki’s representation of their work and contribute to it themselves."'

Droflet:'"Certainly, when we reference particular pieces of work and its implications, the researchers themselves should be stimulated to take an interest and ensure that what is said is accurate!"

--Droflet (talk) 10:54, 8 July 2012 (UTC)