Talk:WikiJournal of Science/Lysenin

Plagiarism check
✅ WMF copyvio tool using TurnItIn. Fully unique content. T.Shafee(Evo&#65120;Evo)talk 09:05, 6 February 2019 (UTC)

For Peer review
I wish to peer review the article Lysenin and dedicate myself for this journal's welfare. Also to gain an opportunity to develop myself further and brush my knowledge and research skills time by time. I completed my Post graduation and M.Phil in Biotechnology. I published 2 research papers in journals and 2 in conference proceedings. Now I am helping and motivating students to pursue in their research.--Sreenandhini (discuss • contribs) 16:26, 6 February 2019 (UTC)
 * Thank you for your offer to help reviewer this article. Whilst we contact specific experts to provide peer reviews, we are always happy to have anyone give feedback on an article in review. I have sent you an email where you can confirm your identity and credentials to . T.Shafee(Evo&#65120;Evo)talk 03:08, 7 February 2019 (UTC)

Spontaneous review
In my view the article entitled “lysenin” is good. But need some modifications and corrections. In my opinion,

a) Abstract: An ideal abstract should be the brief summary of the article (usually not exceeding 200 words) which helps to understand the key points of the article. I think it would be nice to have or expand the abstract with biological role of lysenin also.

b) The lysenin article only focused on the general idea of lysenin interaction, channel oligomerization and pore formation. And the biological information provided is not enough for a good scientific review. Due to these, the article is very far from adequate data. Could you please add more general and applied biological information about lysenin with suitable reference?

c) I think these links will be useful for the lysenin article (biological information).
 * Lysenin, a Novel Bioactive Protein Isolated from Coelomic Fluid of the Earthworm Eisenia foetida - Structure, Secretion and Biological Activity
 * Y. Hirabayashi, Y. Igarashi, A.H. Jr. Merrill;2007;Sphingolipid Biology;Springer Science & Business Media
 * Lawrence W. Miller; 2008;Probes and Tags to Study Biomolecular Function: For Proteins, RNA, and Membranes; John Wiley & Sons.
 * Alberto Diaspro, Marc A. M. J. van Zandvoort; 2016; Super-Resolution Imaging in Biomedicine; CRC Press.

d) Reference : Kindly provide links to the journals in the reference (that can be made more convenient by taking readers to a specific page and also helps to locate the source).

e) I have made some minor changes directly to the article (Corrected the identical reference appeared in multiple times and also provided the links). Kindly go through it. And one thing also, the article needs serious editing with regards to English composition.

I hope the comments will be helpful for the authors.--Sreenandhini (discuss • contribs) 09:08, 15 May 2019 (UTC)

Final before publication non-specialist editorial suggestions

 * 1) Line 1: "Lysenin is a pore-forming toxin in the coelomic fluid of the earthworm Eisenia fetida." to "Lysenin is a pore-forming toxin (PFT) produced by the earthworm Eisenia fetida in its coelomic fluid."
 * 2) Line 2: "Pore-forming toxins (PFTs) are proteinaceous virulence factors produced by many pathogenic bacteria." to "PFTs are often proteinaceous virulence factors produced by many pathogenic bacteria."
 * 3) Line 11: "the most plausible theory is that it is part of an immune-avoiding mechanism. " to "the most plausible theory is that it is part of an immune-avoidance mechanism."
 * 4) Line 13: "There are many proposed technological applications proposed for lysenin, and understanding its molecular role in bacterial infection could help in developing different antibiotic strategies to solve the problem of multiple drug resistance in bacteria." to "The technological applications proposed for lysenin include its molecular role in bacterial infection to help develop different antibiotic strategies for the problem of multiple drug resistance in bacteria."
 * 5) Line 23: "Lysenin is a relatively small water-soluble molecule with a molecular weight of 33 kDa (Figure 1)." to "Lysenin is a relatively small water-soluble molecule (Figure 1) with a molecular weight of 33 kDa."
 * 6)  Line 24: "Using X-ray crystallography, lysenin was classified as a member of the Aerolysin protein family by structure and function." to "Using X-ray crystallography, lysenin was classified as a member of the aerolysin protein family by structure and function."
 * 7)  Line 37: "involving at least three of its phosphatidylcholines (PC) groups." to "involving at least three of its phosphatidylcholines groups." The abbreviation PC isn't used again.
 * 8) Line 44: "The region of the lysenin pore β-barrel expected to be inmersed in the hydrophobic region" to "The lysenin pore β-barrel expected to be immersed in the hydrophobic region".
 * 9) Line 45: "'detergent belt', the 3.2 nm high region occupied by detergent in" to "3.2 nm high 'detergent belt' in".
 * 10) Line 46: "sphingomyelin/Cholesterol" to "sphingomyelin/cholesterol".
 * 11) Line 54: "As with most PFTs, lysenin oligomerization occurs in a two-step process, as was recently imaged." to "As with most PFTs, lysenin oligomerization occurs in a two-step process recently imaged."
 * 12) Line 63: "Determining the prepore's structure by X-ray or Cryo-EM is a challenging process that so far has not produced any results." to "Determining the prepore's structure by X-ray or Cryo-EM has not produced results."
 * 13) Line 66: "and the width 118 Å" to "and the diameter 118 Å".
 * 14) Line 68: "A recent study in aerolysin suggests that the currently accepted model for the lysenin prepore should be revisited, according to the new available data on the aerolysin insertion." to "A recent study of aerolysin insertion suggests that the currently accepted model for the lysenin prepore should be revisited."
 * 15) Line 83: "and glutamic acids are found in aerolysin family members in its PFMs." to "and these are found in aerolysin family members."
 * 16) Line 91: "width 115 Å" to "diameter 115 Å".
 * 17) Line 94: "a mechanism that could be general to all β-PFTs. The first hint of crowding effect on" to "a mechanism that may occur in all β-PFTs. The first hint of crowding on".
 * 18) Line 95: "High-Speed AFM studies incubating lysenin on sphingomyelin/cholesterol membranes has shown" to "High-Speed AFM studies incubating lysenin on sphingomyelin/cholesterol membranes have shown".
 * 19) Line 99: "however, it is through to induce apoptosis via three possible hypotheses:" to "however,  apoptosis can be induced via three possible hypotheses:". --Marshallsumter (discuss • contribs) 17:40, 9 August 2019 (UTC)