User:Graeme E. Smith/GreySmith Allocortical Tissue Protocol 1

{{User:Graeme_E._Smith/GreySmith Article Framework| Heading = GreySmith Allocortical Tissue Protocol 1| Subheading = Testing Allocotical Tissue for Implicit/Explicit Access| Author=Graeme E. Smith| Abstract = Cortex Tissue can be separated according to micro-architecture, into areas that have 6 layers and are called Isocortical, or Granular, areas that have 5 layers because their 4th layer is attenuated or missing and are called AGranular, and areas that have 4 or less layers which are called Allocortical. Although the Allocortex is probably the largest area of Allocortical tissues, There are many places throughout the brain where Allocortical tissue can be found. While working on a Neuro-Psycho-Architectural theory of memory, I hypothesised that Allocortical Tissue was implicit memory with no explicit access, and that Isocortical Tissue had both Implicit and explicit access. In this article I describe a protocol that might be used to indicate with greater certainty whether in fact this is the case. I call it the GreySmith Allocortical Tissue Protocol 1 or GSATP1 for short. Body= {{indent|8}}To test the theory that Allocortical Tissue is Implicit memory with no Explicit Access, we need to test both Allocortical tissue and Isocortical Tissue so that we can dissociate between them, and we need to test for implicit and explicit memory so that we can dissociate between them. This creates essentially a 4 box 2 dimensional array where the results of the tests should indicate the access potential of both Isocortical and Allocortical memory.{{indent|9}}What we are looking for is the condition where the Isocortical line of the array shows both implicit and explicit access, and the Allocortical line of the array shows only implicit access. Any other solution can be seen to be a disproof of the hypothesis.{{indent|8}}To be able to support or disprove the hypothesis, we need to do sufficient controls to assure ourselves that we can dissociate between Isocortical and Allocortical Tissues and between implicit and explicit memories. To create a control for Isocortical and Allocortical tissues we must pick tissues that are known to be one or the other, and test for cross contamination of our results. A signal thought to be handled by an Allocortical tissue, must not impact on the action of a test for an Isocortical Tissue and visa versa. We can do this by isolating the test stimuli, by sensory modality. For instance for our Isocortical Test we could use the Visual System, and for our Allocortical Test we could use the Olfactory Bulb. We could then test some of the subjects by giving them the test for an olfactory stimulus with only a visual stimulus, and test some of the subjects by giving them the test for a visual stimulus with only an olfactory stimulus, and thus prove that the two routes through the memory were discrete. Care must be taken to manage the population of controls so that they have a statistical significance.{{indent|8}}The next problem is how to Dissociate the implicit from explicit memory. The job here is to take advice of the fact that implicit memory responds to priming, while explicit memory doesn't, and Explicit memory responds despite delays between stimulus and response, and implicit memory doesn't. The test factors are speed of response which indicates priming, and delay length which eliminates priming as a factor. So in order to test our experiment we need to do controls which test the speed of response after a delay, and controls that test speed of response for different delay lengths to show when priming is no longer a factor. Those tests then determine the minimum delay length we can use to eliminate priming in tests of explicit memory By judicious choice of a longer delay length than the minimum indicated we can virtually eliminate priming as a factor in explicit memory tests. Now that we have proven our test as dissociating the four factors in tuples, we need to test for cross contamination between the diagonal arrangements of the tests. This should be possible with statistical means. We can test our output results for all four lobes, by eliminating two lobes and testing the other two lobes for statistical cross-over.{{indent|8}}once we have our control system in place, the next problem is how to test for the experimental conditions. Up until now I have glossed over what the actual tests are in order to point out how to control them. We need 4 tests, One visual priming test, one Visual delayed response test, hopefully similar enough that we are testing the same area of the brain, one Olfactory priming test, and one Olfactory delayed response test, with a similar provisio. A Statistically significant number of mice should be run through the test a statistically significant number of times, and then the results tabulated and statistically analyzed, and projected onto the 4 area 2 dimensional graph suggested above to indicate the accuracy of the hypothesis. I leave the choice of the particular tests to the individual researcher, since this test should hold true with multiple test conditions as long as the tests do what they are supposed to do.

Conclusion
While I haven't declared any specific olfactory and visual tests for this protocol, as long as the tests can be clearly seen to dissociate priming from delayed response with different periods of response delays that are long enough to eliminate priming and compare the speed of response between the immediate response tests and the delayed response tests, and as long as the controls are managed properly this test should clearly show whether or not the hypothesis that Allocortical Tissues are Tissues without explicit access and Isocortical Tissue have both implicit and explicit access, which are the conditions required for my hypothesis to be supported. The 2 dimensional graph with the results tabulated in it, would indicate the success of the experiment. category=GreySmith/Psychology|}}